Vitamin K3 derivative induces apoptotic cell death in neuroblastoma via downregulation of MYCN expression
نویسندگان
چکیده
منابع مشابه
Apoptotic Cell Death in Neuroblastoma
Neuroblastoma (NB) is one of the most common malignant solid tumors in childhood, which derives from the sympathoadrenal lineage of the neural crest and exhibits extremely heterogeneous biological and clinical behaviors. The infant patients frequently undergo spontaneous regression even with metastatic disease, whereas the patients of more than one year of age who suffer from disseminated disea...
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MYCN amplification strongly predicts adverse outcome of neuroblastoma. However, the significance of MYCN expression in the clinical and biological behavior of neuroblastoma has been unclear. To address this question, we first examined the expression of MYCN in combination with TrkA (a favorable prognostic indicator of neuroblastoma) in 91 primary neuroblastoma by quantitative reverse transcript...
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ژورنال
عنوان ژورنال: Biochemistry and Biophysics Reports
سال: 2019
ISSN: 2405-5808
DOI: 10.1016/j.bbrep.2019.100701